2005: Breakthrough: Cellectis enables the industrial production of nucleases

Cellectis research teams provide proof of the in vivo efficacy of meganucleases, the molecular "scissors" that enable us to precisely reprogram the genome of any living organism as needed – be it human, animal, vegetable, bacterium, or virus. Gene editing is born, and with it the possibility to industrialize a once unpredictable, predominantly manual science. A tremendous leap forward for researchers, pharmaceutical laboratories, and seed producers alike.

2007: Listing on the Euronext Growth market of Euronext market of Euronext in Paris

With its impressive patent portfolio and enormous potential for growth, Cellectis makes a successful initial public offering on the Euronext Growth market of Euronext in Paris (21.2 million Euros).

2008 – 2010: Acquisition of technologies and establishment of subsidiaries

2010: Acquisition of all assets of CytoPulse Inc., based in Maryland

The acquisition included Hybrimune electrofusion technology and PulseAgile technology for RNA transfection by electroporation. PulseAgile is now the standard technology for RNA transfection of T-cells.

2010: Founding of Cellectis plant sciences, Inc. (now Calyxt, Inc.)

2011: TAL nucleases patents are exclusively licensed to Cellectis by the University of Minnesota

2014: Strategic collaboration agreement with Servier

In February, Cellectis and Servier announce collaboration in allogeneic cell therapy to develop and commercialize novel product candidates targeting leukemia and other potential tumors.

2014: Global strategic cancer immunotherapy collaboration with Pfizer

In June, Pfizer and Cellectis enter into global strategic cancer immunotherapy collaboration to develop immunotherapies against selected targets in the field of oncology.

2015: Listing on the Nasdaq Global market in New York

As the first company to create allogeneic CAR T-cells from healthy donors rather than from the patients themselves, Cellectis makes the second largest IPO in the CAR T space with a total of 228.250 million USD.

2015: First-in-man compassionate use of UCART19 for acute lymphoblastic leukemia (ALL)

In November, Cellectis announced that Great Ormond Street Hospital (GOSH) and University College London (UCL) will present encouraging data from a first in man clinical use of UCART19, at the 57th American Society of Hematology (ASH) Annual Meeting in Orlando during the poster session.

2016: Ongoing clinical trials of UCART19

Two ongoing clinical studies of UCART19 product candidate have started in June 2016. The first one is a Phase 1 pediatric study sponsored by Servier and conducted by University College London, UK in patients with acute lymphoblastic leukemia (ALL). The second one is a Phase 1 adult study sponsored by Servier and conducted by King’s College London, UK in patients with acute lymphoblastic leukemia (ALL).

2018: Global strategic collaboration agreement originally formed between Cellectis and Pfizer in 2014 is assumed by Allogene

2018: Closing of a $175 million U.S. public offering

2019: Cellectis Enters Lease Agreement to Build Manufacturing Facility, Advancing Towards Commercialization of its UCART Portfolio

2019: 1st Patient Dosed with Cellectis' Allogeneic UCART22 in Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia

On December 2, the Company announced the first patient enrolled in the dose escalation Phase 1 clinical study for its UCART22 product candidate had been dosed at The University of Texas MD Anderson Cancer Center. This clinical study, BALLI-01, evaluates the safety, expansion, persistence and clinical activity of UCART22 in patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL).

2020: 1st Patient Dosed with Cellectis’ New Allogeneic UCART123 Product Candidate in Relapsed/Refractory Acute Myeloid Leukemia for the AMELI-01 Clinical Trial

On January 15, Cellectis announced that the first patient had been dosed at The University of Texas MD Anderson Cancer Center in AMELI-01, a Phase 1 clinical trial that uses a new UCART123 construct with an optimized production process and new IND number from the FDA. The AMELI-01 study replaces the first US clinical trial assessing the UCART123 product candidate.

2022: Cellectis' Two Manufacturing Sites Are Fully Operational

On March 3, Cellectis announced that its starting materials manufacturing facility in Paris (55,000 square feet), France is now fully operational, focusing on the production of starting materials including plasmids and mRNA for its TALEN® gene editing technology, and viral vectors for use in clinical manufacturing.

Cellectis’ UCART GMP manufacturing facility in Raleigh, North Carolina (82,000 square feet) is now fully operational, focusing on its clinical and commercial UCART manufacturing operations as well as manufacturing and release testing of batches of its product candidates.

2022: 1st Patient Dosed with Cellectis' In-house Manufactured Product Candidate UCART22 for B-cell ALL

2022: IND Clearance received for UCART20x22, Cellectis' First In-house Manufactured Product Candidate for the Treatment of B-cell Malignancies

2023: Cellectis Announces Strategic Collaboration and Investment Agreements with AstraZeneca

Cell & Gene Therapy R&D Collaboration:

• Develop up to 10 novel products in oncology, immunology and rare diseases
• $25M upfront
• Milestones from $70M to $220M per product with tiered royalties
• AstraZeneca to cover Cellectis' research costs

Investment Agreement:

• $80M initial equity investment (subscribed for 16 million ordinary shares at $5.00 per share)
• Potential $140M additional equity investment (28 million convertible preferred share at $5.00 per share), subject to shareholders' approval, FDI clearance, and other customary closing conditions