Scientific publications

Targeting CD123 in blastic plasmacytoid dendritic cell neoplasm using allogeneic anti-CD123 CAR T cells

Roman Galetto, Agnès Gouble
Nature Communications
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Allogeneic TCRαβ deficient CAR T-cells targeting CD123 in acute myeloid leukemia

Roman Galetto, Agnès Gouble
Nature Communications
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Straightforward Generation of Ultrapure Off-the-Shelf Allogeneic CAR-T Cells

Alexandre Juillerat, Diane Tkach, Ming Yang, Alex Boyne, Julien Valton, Laurent Poirot and Philippe Duchateau
Frontiers in Bioengineering and Biotechnology June 25, 2020
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Allogeneic FLT3 CAR T cells with an off-switch exhibit potent activity against acute myeloid leukemia and can be depleted to expedite bone marrow recovery

Cesar Sommer, Hsin-Yuan Cheng, Duy Nguyen, Danielle Dettling, Yik Andy Yeung, Janette Sutton, Moustafa Hamze, Julien Valton, Julianne Smith, Ivana Djuretic, Javier Chaparro-Riggers, Barbra J. Sasu
Molecular Therapy June 15, 2020
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Off-the-shelf allogeneic CAR T cells: new development and current challenges

S. Depil, P. Duchateau, S. A. Grupp, G. Mufti and L. Poirot
Nature Review Drug Discovery January 3, 2020
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Repurposing Endogenous Immune Pathways to Tailor and Control Chimeric Antigen Receptor T-cell Functionality

Mohit Sachdeva, Brian W. Busser, Sonal Temburni, Billal Jahangiri, Anne-Sophie Gautron, Alan Maréchal, Alexandre Juillerat, Alan Williams, Stéphane Depil, Philippe Duchateau, Laurent Poirot and Julien Valton
Nature Communications November 2019
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Modulation of Chimeric Antigen Receptor surface expression by a small molecule switch

Alexandre Juillerat, Diane Tkach, Brian W. Busser, Sonal Temburni, Julien Valton, Aymeric Duclert, Laurent Poirot, Stéphane Depil and Philippe Duchateau
BMC Biotechnology (2019); Published Online: https://doi.org/10.1186/s12896-019-0537-3
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Granulocyte-macrophage colony-stimulating factor inactivation in CAR T-Cells prevents monocyte-dependent release of key cytokine release syndrome mediators

Mohit Sachdeva, Philippe Duchateau, Stéphane Depil, Laurent Poirot and Julien Valton
Journal of Biological Chemistry; Published Online: doi: 10.1074/jbc.AC119.007558
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Understanding the indirect DNA read-out specificity of I-CreI Meganuclease

Jesús Prieto, Pilar Redondo, Blanca López-Méndez, Marco D’Abramo, Nekane Merino, Francisco J. Blanco, Phillipe Duchateau, Guillermo Montoya & Rafael Molina
Scientific Reportsvolume 8, Article number: 10286 (2018) July 6, 2018
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A Versatile Safeguard for Chimeric Antigen Receptor T-Cell Immunotherapies

Julien Valton, Valerie Guyot, Bijan Boldajipour, Cesar Sommer, Thomas Pertel, Alexandre Juillerat, Aymeric Duclert, Barbra Johnson Sasu, Philippe Duchateau & Laurent Poirot
Scientific Reportsvolume 8, Article number: 8972 (2018) June 12, 2018
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