03 Sep 2024
11:08 E.S.T.

Multi-armored allogeneic MUC1 CAR T cells enhance efficacy and safety in triple-negative breast cancer

Piril Erler, Tomasz Kurcon, Hana Cho, Jordan Skinner, Chantel Dixon, Steven Grudman, Sandra Rozlan, Emilie Dessez, Ben Mumford, Sumin Jo, Alex Boyne, Beatriz Aranda-Orgilles, Alexandre Juillerat, Philippe Duchateau and Laurent Poirot
Science Advances

26 Aug 2024
10:40 E.S.T.

TALEN-edited Allogeneic Inducible Dual CAR T-cells Enable Effective Targeting of Solid Tumors while Mitigating Off-Tumor Toxicity

Sonal Dharani, Hana Cho, Jorge Postigo Fernandez, Alexandre Juillerat, Julien Valton, Philippe Duchateau, Laurent Poirot and Shipra Das
Molecular Therapy

20 Jun 2024
16:30 E.S.T.

Comprehensive analysis of the editing window of C-to-T TALE base editors

Maria Feola, Sylvain Pulicani, Diane Tkach, Alex Boyne, Robert Hong, Louisa Mayer, Aymeric Duclert, Philippe Duchateau & Alexandre Juillerat
Scientific Reports

12 Jun 2024
10:36 E.S.T.

Non-viral DNA delivery and TALEN editing correct the sickle cell mutation in hematopoietic stem cells

Arianna Moiani, Gil Letort, Sabrina Lizot, Chloé Foray, Diane Le Clerre, Sonal Temburni-Blake, Patrick Hong, Sophie Leduc, Noémie Pinard, Alan Marechal, Eduardo Seclen, Alex Boyne, Louisa Mayer, Anne Chalumeau, Tristan Felix, Robert Hong, Sylvain Pulicani, Roman Galetto, Agnès Gouble, Marina Cavazzana, Alexandre JUillerat, Annarita Miccio, Aymeric Duclert, Philippe Duchateau & Julien Valton
Nature Communications

10 Apr 2024
10:29 E.S.T.

TALEN-mediated intron editing of HSPCs enables transgene expression restricted to the myeloid lineage

Julien Valton, Philippe Duchateau, Alexandre Juillerat, Alex Boyne, Eduardo Seclen, Jessica C. Jang, Aminah O.Lawal, Sylvain Pulicani and Diane Tkach
Molecular Therapy

31 May 2023
16:36 E.S.T.

Preclinical Evidence of an Allogeneic Dual CD20xCD22 CAR to Target a Broad Spectrum of Patients with B-cell Malignancies

Beatriz Aranda-Orgilles ; Isabelle Chion-Sotinel ; Jordan Skinner ; Steven Grudman ; Ben Mumford ; Chantel Dixon ; Jorge Postigo Fernandez ; Piril Erler ; Phillipe Duchateau ; Agnes Gouble ; Roman Galetto ; Laurent Poirot
Cancer Immunology Research

12 May 2023
04:55 E.S.T.

Stromal depletion by TALEN-edited universal hypoimmunogenic FAP-CAR T cells enables infiltration and anti-tumor cytotoxicity of tumor antigen-targeted CAR-T immunotherapy

Shipra Das, Julien Valton, Philippe Duchateau, Laurent Poirot
Frontiers in Immunology

10 Nov 2022
02:30 E.S.T.

Efficient multitool/multiplex gene engineering with TALE-BE

Alex Boyne, Alexandre Juillerat, Sylvain Pulicani, Maria Feola, Diane Tkach, Robert Hong, Aymeric Duclert, Philippe Duchateau
Frontiers in Bioengineering and Biotechnology

30 Jun 2022
09:39 E.S.T.

Endowing universal CAR T-cell with immune-evasive properties using TALEN-gene editing

Julien Valton, Shipra Das, Siumin Jo
Nature Communications

28 Apr 2022
09:00 E.S.T.

Targeting CD123 in blastic plasmacytoid dendritic cell neoplasm using allogeneic anti-CD123 CAR T cells

Roman Galetto, Agnès Gouble
Nature Communications

Scientific publications

Multi-armored allogeneic MUC1 CAR T cells enhance efficacy and safety in triple-negative breast cancer

TALEN-edited Allogeneic Inducible Dual CAR T-cells Enable Effective Targeting of Solid Tumors while Mitigating Off-Tumor Toxicity

Comprehensive analysis of the editing window of C-to-T TALE base editors

Non-viral DNA delivery and TALEN editing correct the sickle cell mutation in hematopoietic stem cells

TALEN-mediated intron editing of HSPCs enables transgene expression restricted to the myeloid lineage

Preclinical Evidence of an Allogeneic Dual CD20xCD22 CAR to Target a Broad Spectrum of Patients with B-cell Malignancies

Stromal depletion by TALEN-edited universal hypoimmunogenic FAP-CAR T cells enables infiltration and anti-tumor cytotoxicity of tumor antigen-targeted CAR-T immunotherapy

Efficient multitool/multiplex gene engineering with TALE-BE

Endowing universal CAR T-cell with immune-evasive properties using TALEN-gene editing

Targeting CD123 in blastic plasmacytoid dendritic cell neoplasm using allogeneic anti-CD123 CAR T cells