Cellectis' product candidates, based on allogeneic gene-edited T-cells that express Chimeric Antigen Receptors, or CARs, seek to harness the power of the immune system to target and eradicate cancers. A key to this effort is a type of white blood cell known as the T-cell, which plays an important role in identifying and killing cancer cells. Unfortunately, cancer cells often develop mechanisms to evade the immune system. CARs, which are engineered receptors that can be expressed on the surface of the T-cell, provide the T-cell with a specific targeting mechanism, thereby enhancing its ability to seek, identify, interact with and destroy tumor cells bearing a selected antigen. Cellectis is designing next-generation immunotherapies that are based on gene-edited CAR T-cells. Our gene-editing technologies allow us to create allogeneic CAR T-cells, meaning they are derived from healthy donors rather than the patients themselves.

Cellectis is developing innovative allogeneic immunotherapies using its gene editing expertise to treat certain cancers. Cellectis product candidates are in development stage and are not authorized for commercialization.

Cellectis' pipeline, which keeps track of our product candidates' development, is constantly evolving. This pipeline is available under the Products section, Products candidates subsection.

Cellectis’ shares are listed on the Euronext Growth market of Euronext in Paris under ISIN code FR0010425595 and the ticker symbol ALCLS. In the U.S., they are also listed on the Nasdaq Global Market under the ticker symbol CLLS.

Trading began on February 7, 2007 on the Euronext Growth market of Euronext in Paris, and on March 25th, 2015 on the Nasdaq Global Market in the U.S.

At Cellectis, we attach great importance to the protection of our technology, intellectual property rights and our patents, and we take an active approach to defending our intellectual property.

As of November 30, 2024 the number of shares constituting Cellectis’ capital is 100,093,873. As of the same date, the total number of voting rights is 88,576,206.

To purchase Cellectis shares, you must have an account with a financial intermediary (bank, brokerage firm, online broker, etc.) and place your order through them.

Every year, Cellectis publishes a business report on the preceding year, which can be found on our website; this document can also be sent to you on request. In addition, Cellectis files a 20-F form with the SEC, available on our website. Our press releases can also be found on our website under the Press section.

If you are a holder of Cellectis shares, you can participate in Shareholders’ General Meetings. To attend, send a proxy, or vote by mail, you must have your shares booked as registered shares with the Company or bearer shares with an authorized intermediary, no later than three business days before the date of the Meeting. For more information, go to Investors section, General Meetings subsection. If you are holder of ADS, please contact our depositary of ADS.

Each shareholder has as many votes as are conferred by the number of Cellectis shares he/she owns or represents. Rather than personally attending a Meeting, you may vest another shareholder or your spouse with power of attorney to represent you by proxy. For more information, go to Investors section, General Meetings subsection.

For the time being, we do not pay dividends to our shareholders because, like the vast majority of biotechnology companies, Cellectis does not yet generate profits.

A liquidity provider’s agreement is a signed contract between a securities issuer and an investment services provider whose role it is to buy or sell shares of the issuing company if the market for those shares becomes unbalanced or illiquid. The investment services provider thus contributes additional liquidity to the company’s shares and enhances the flow of transactions.

For the sake of transparency, our press releases include the financial terms of our main agreements insofar as we are authorized.

A glossary of terms specific to Cellectis’ business activities is available on our website, under Glossary (in the footer of each page).