Careers at Cellectis
Our business draws on a wide range of job skills and includes people with different academic backgrounds, career histories, and experience. At Cellectis, every position helps our company excel. Read below about some of the jobs held in our various business lines.
Researchers are high-level scientists who specialize in a specific field. A researcher manages one or more projects and works with a team to draw up and carry out experimental protocols, as well as to analyze and interpret the results. Researchers showcase their results and present technological developments to the scientific community by publishing and participating in colloquia. They also file licenses and patents. Researchers are experts in their fields and work actively to stay abreast of the latest scientific developments.
Engineers report directly to researchers. They are technology experts who participate in projects by designing and carrying out experiments, as well as analyzing results. Engineers know the possibilities and limits of the techniques being used, and can share their expertise with colleagues.
Technicians work under the supervision of a researcher or engineer. They perform experiments and are in charge of correctly implementing protocols and managing results.
The goals of preclinical studies are to demonstrate the anti-tumor activity of the UCART product candidates, to study their mechanism of action and to assess their potential toxicity following administration to patients. Those studies are conducted both in vitro and in vivo in animal models in association with a risk-benefit analysis performed in the context of the particular clinical indication under study. Preclinical studies are part of the Clinical Trial Authorization application and the Marketing Authorization application (AMM, or Autorisation de Mise sur le Marché in French).
GMP Manufacturing & Solutions
GMP, or Good Manufacturing Practices are a set of regulations applicable to the manufacturing of health products, especially medicines intended for human use, such as UCART products for example. A company is required to comply with GMP regulations, in order to be granted from governmental regulatory agencies, its license to manufacture pharmaceutical products. The GMP Manufacturing & Solutions department takes manufacturing processes established at R&D level, converts them to GMP, and ensures their deployment with GMP compliant raw materials and environments. The department is responsible for the manufacturing of clinical trial material (“CTM”), making it available for clinical studies and afterwards, and also for the manufacturing of final GMP commercial cellular gene therapy products. The team interacts internally with different departments and groups ranging from development, planning, to regulatory and legal, as well as externally as the Cellectis contact point for the raw materials contractors or the GMP manufacturing contract organizations.
Intellectual property is very important to Cellectis. The Group invests more than half its budget in research and development in order to fine-tune new genome engineering techniques. An in-house team of patent engineers, in conjunction with external European and American consulting firms, is responsible for writing patent applications. Our patents concern reagents used to cut DNA and their various applications in genome engineering, such as modified immune cell lines, and new plant varieties. Many of our patents have been licensed to other companies, which helps leverage our intellectual property and to enter into collaboration agreements. Cellectis has also acquired licenses for the right to implement other people’s patents deemed useful also identified by our patent department.
The main tasks of the Program Planning team are part of a comprehensive (transversal) management strategy:
- Preparation of assembly and steering tools for Cellectis internal programs and internal deployment of these tools;
- Coordination (with other departments or committees) in the context of possible changes to programs;
- Follow-up (with the help of other departments or committees) for the advancement status of programs.